Hi, we’re HDAX

We are dedicated to bringing transformative therapies to patients – empowering them to embrace life to its fullest.

Our Story

Born out of the lab of Professor Patrick Gunning, a serial entrepreneur with a successful track record, at the University of Toronto, HDAX Therapeutics was created with a foundation in translational science and a mission to advance revolutionary treatments.

Our entrepreneurial drug developers have taken the technology behind HDAX from concept to derisked programs with therapeutic potential in cardiorenal and metabolic diseases, neuropathies and more. We are backed by an experienced network of advisors and investors, and are focused on turning our chemistry into treatments that reach patients.

Our Team

HDAX has a unique blend of experienced drug developers and passionate founders equipped with scientific background and business expertise to lead the future of precision HDAC6 targeting for diseases with high unmet needs.

Team

Nabanita Nawar, PhD

Nabanita Nawar, PhD

CEO & Co-founder

Nabanita Nawar, PhD

CEO & Co-founder

Dr. Nawar received her PhD in Medicinal Chemistry at the University of Toronto. Her expertise in drug discovery, leadership, governance and science policy, fuels HDAX’s growth through her forward-thinking vision. Recognized as the ‘2022 Rising Star’ by the Ontario Institute for Cancer Research for her leadership and innovation, Nabanita boasts an impressive portfolio including 10 high impact publications, 2 patent applications, and over 20 awards including Top Scholar at the University of Toronto, The Society of Chemical Industry Merit Award and the Canadian Silver Medal from the Chemical Institute of Canada. HDAX Tx has won over 10 recognitions and awards under her leadership, notably Effervescence Pan-Canadian Start-up Competition 2022, Medicine by Design 2021 and Sweet Pharma Day 2021.

Pimyupa Manaswiyoungkul, PhD

Pimyupa Manaswiyoungkul, PhD

COO & Co-founder

Pimyupa Manaswiyoungkul, PhD

COO & Co-founder

Dr. Manaswiyoungkul brings a wealth of expertise from her background in biophysical chemistry, biochemistry and business. With degrees from the University of Waterloo and University of Toronto, she has published 14 articles, contributed to 2 patents, and received numerous academic awards. Her strategic vision at HDAX is informed by her experiences in project management, strategy consulting, business development, and training from The Wharton School, CFA Institute, and top consulting firms. Pimyupa seamlessly blends scientific knowledge and business acumen to drive operational success.

Nicholas Terrett, PhD

Nicholas Terrett, PhD

Head of Medicinal Chemistry

Nicholas Terrett, PhD

Head of Medicinal Chemistry

Nick Terrett is a medicinal chemist who was educated at the University of Cambridge, and has worked in drug discovery for over 40 years in both large pharmaceutical (GSK, Pfizer, Merck) and small biotech companies (Ensemble Therapeutics) in the US, UK, and Switzerland. He has advanced several candidates into the clinic and was chemistry leader and inventor for sildenafil (marketed as ViagraTM and RevatioTM). Nick has promoted new drug discovery technologies establishing Pfizer’s first combinatorial chemistry platform and while at Ensemble Tx developed DNA-encoded chemistry libraries and explored macrocycles as valuable ‘beyond Rule of 5’ drug modalities.

LinkedIn +

Board of Directors

Roman Fleck, PhD

Roman Fleck, PhD

Director

Roman Fleck, PhD

Director

Dr Fleck currently serves as CEO of Janpix, Inc., an oncology-focused discovery and development company, and is the Chairman of Omniose, a bacterial vaccine discovery company. Previously, he was a Venture Advisor/Partner with Medicxi Ventures following his role as a Principal where among others he invested in and represented Medicxi Ventures on the boards of GlycoVaxyn (sold to GSK), Versartis (NASDQ: VSAS), and Novocure (NASDQ: NVCR). Earlier he was also involved in Funxional Therapeutics (sold to Boehringer Ingelheim) and Micromet (sold to Amgen). Prior to his venture career he worked at Boehringer Ingelheim where he led drug development projects in oncology, inflammation and cardiovascular disease, advancing several compounds from pre-clinical to clinical stage. Roman received a PhD from MIT as well as an MBA from NYU Stern.

Neal Muni, M.D., MSPH

Neal Muni, M.D., MSPH

Director

Neal Muni, M.D., MSPH

Director

Dr Muni brings over 20 years of industry experience as an operator, investor, board member and advisor to multiple biotechnology and pharmaceutical companies. Neal currently serves as the Managing Director of RTK Group – a biopharmaceutical advisory and investment practice supporting clinical stage companies from development to commercialization – as well as Chief Operating Officer of Comera Life Sciences (NASDAQ: CMRA) and Chief Medical Officer of Unravel Biosciences, and was previously the CEO of Azurity Pharmaceuticals. Neal maintains staff appointments as Instructor in Medicine and Associate Physician at Harvard Medical School and Brigham and Women’s Hospital and is a Visiting Scholar at The Wyss Institute of Harvard University.

Brock Reeve

Brock Reeve

Director

Prakash Gowd, MBA

Prakash Gowd, MBA

Director

Advisors

Bertrand Le Bourdonnec, PhD

Scientific Advisor

Bertrand Le Bourdonnec, PhD

Scientific Advisor

Dr. Le Bourdonnec has over 20 years experience in the Biotech industry. He’s led multiple projects from early Research to Clinical Development across multiple therapy areas (pain, gastro-intestinal disorders, infectious diseases, neurodegenerative diseases and oncology).  Prior to HDAX Therapeutics, he served as VP Chemistry and Pre-Clinical Development at Deciphera Pharmaceuticals.  Previously, he led several R&D functions at Yumanity Therapeutics and contributed to the company’s growth from early start-up to a Clinical stage organization. Earlier in his career, Dr. Le Bourdonnec was at Cubist Pharmaceuticals, initially in the Development group as Clinical Program Leader, and later in the Research group as VP Chemistry and Pharmaceutics. Dr. Le Bourdonnec holds a Chemical Engineering degree and a PhD in Organic Chemistry from the University of Lille. He also completed a Post-Doctoral fellowship in the laboratory of Professor Portoghese at the University of Minnesota. He is an inventor on over 90 patents and has published his research in over 30 scientific articles.

Professor Patrick Gunning, PhD

Co-Founder

Professor Patrick Gunning, PhD

Co-Founder

Prof Gunning is a Canada Research Chair and the inaugural Scientific Director of the Centre for Medicinal Chemistry (CMC). Patrick’s entrepreneurial spirit has catalysed the formation of multiple spin-off companies from his research group, attracting a total investment of >$50 million. Notably, he recently closed a $1.3 billion strategic partnership between the CMC spin-off Dunad Therapeutics, and Novartis. Across 15 years at the University of Toronto, Patrick has trained over 60 researchers, published upwards of 130 manuscripts, submitted >20 patents and delivered ~150 lectures. His work has been celebrated with over 20 national and international awards, including Canada’s Top 40 under 40.

Professor Ahmet Hoke, PhD

Scientific and Clinical

Professor Ahmet Hoke, PhD

Scientific and Clinical

Dr Hoke is Professor of Neurology and Neuroscience, W. W. Smith Charitable Trust Professor of Neuroimmunology, and Director of both the Daniel B. Drachman Division of Neuromuscular Diseases and the Merkin Peripheral Neuropathy and Nerve Regeneration Center at Johns Hopkins University School of Medicine. Both Ahmet’s clinical practice and research focuses on the mechanism and treatment of peripheral neuropathies. Across decades of experience he has attracted numerous accolades, including the 2022 Alan J. Gebhart Prize in Excellence in Neuropathy Research. Ahmet is an ex officio member of the American Neurological Association Board of Directors, Vice President of the Toxic Neuropathy Consortium and Editor-in-Chief of Annals of Clinical and Translational Neurology.

Our Partners

HDAX has partnered with renowned investors, accelerators, and institutions who share our vision of a better treatment paradigm.

  • Berkeley SkyDeck
  • FACIT
  • Mitacs
  • Ontario Bioscience Innovation Organization
  • TIAP
  • University of Toronto
  • Ontario Centre of Innovation
  • EOS
  • Seedfolio
  • VitaDAO
Contact Grid

Do you share our vision?

Be the first to know our next discoveries.

Get In Touch